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M9630189.TXT
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1996-02-27
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Document 0189
DOCN M9630189
TI [Phenotype of lymphocytes in bronchoalveolar lavage fluid of patients
with lung fibrosis in the course of scleroderma]
DT 9603
AU Domagala-Kulawik J; Hoser G; Doboszynska A; Kawiak J; Droszcz W; Kliniki
Pneumonologii AM w Warszawie.
SO Pneumonol Alergol Pol. 1995;63(7-8):382-8. Unique Identifier : AIDSLINE
MED/96106086
AB Patients with systemic sclerosis frequently develop interstitial lung
disease. One of the major sites of pathogenic activity are lymphocytes
from lung interstitium. The purpose of this work was phenotype analysis
of lymphocytes in bronchoalveolar lavage fluid (BALF) with flow
cytofluorometry. We found an increase number of CD8+ lymphocytes and
CD8+/T ratio, and an reduced CD4+/CD8+ ratio in patients when compared
to healthy volunteers. The diffusing capacity (DLCO) correlated positive
with percentage of neutrophils and HLA-DR+ lymphocytes. There are the
features of mixed type alveolitis in patients with short disease
duration. We found increase number of lymphocytes, neutrophils, CD8+
lymphocytes, HLA-DR+ lymphocytes and CD25+ lymphocytes in this patients.
We concluded that fluorocytometric BALF analysis may be useful for the
diagnosis and management of lung involvement in patients with
scleroderma before the treatment.
DE Adult Aged Antigens, Differentiation/ANALYSIS Bronchoalveolar Lavage
Fluid/*CYTOLOGY/IMMUNOLOGY CD4 Lymphocyte Count English Abstract
Female Fluoroimmunoassay Human HLA-DR Antigens/ANALYSIS
Immunophenotyping Male Middle Age Pulmonary
Fibrosis/DIAGNOSIS/*IMMUNOLOGY Scleroderma, Systemic/*IMMUNOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).